Copper and copper-based catalysts can electrochemically convert CO2 into ethylene and higher alcohols, among other products, at room temperature and pressure. This approach may be suitable for the production of high-value compounds. However, such a promising reaction is heavily burdened by the instability of copper during CO2 reduction. To date, non-copper catalysts have also failed to supplant the activity and selectivity of copper, leaving CO2-to-C2 electrolysis in the balance. In this Perspective, we discuss copper catalyst instability from both the atomistic and the microstructure viewpoint. We motivate that increased fundamental understanding, material design and operational approaches, along with increased reporting of failure mechanisms, will contribute to overcoming the barriers to multi-year operation. Our narrative focuses on the copper catalyst reconstruction occurring during CO2 reduction as one of the major causes inducing loss of C2 activity. We conclude with a rational path forward towards longer operations of CO2-to-C2 electrolysis.