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  4. Lipid membrane deformation in response to a local pH modification: theory and experiments
 
research article

Lipid membrane deformation in response to a local pH modification: theory and experiments

Bitbol, Anne-Florence  
•
Puff, Nicolas
•
Sakuma, Yuka
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2012
Soft Matter

We study the deformation of a lipid membrane in response to a local pH modification. Experimentally, a basic solution is microinjected close to a giant unilamellar vesicle. A local deformation appears in the zone of the membrane that is closest to the micropipette, and relaxes when the injection is stopped. A theoretical description of this phenomenon is provided. It fully takes into account the spatiotemporal evolution of the concentration of hydroxide ions during and after the microinjection, as well as the linear dynamics of the membrane. This description applies to a local injection of any substance that reacts reversibly with the membrane lipids. We compare experimental data obtained in the domain of small deformations to the results of our linear description, and we obtain a good agreement between theory and experiments. In addition, we present direct experimental observations of the pH profile on the membrane during and after the microinjection, using pH-sensitive fluorescent lipids.

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Type
research article
DOI
10.1039/c2sm25519g
Web of Science ID

WOS:000304100900015

Author(s)
Bitbol, Anne-Florence  
Puff, Nicolas
Sakuma, Yuka
Imai, Masayuki
Fournier, Jean-Baptiste
Angelova, Miglena I.
Date Issued

2012

Publisher

Royal Society of Chemistry (RSC)

Published in
Soft Matter
Volume

8

Issue

22

Article Number

6073

Subjects

Long-Range Forces

•

Heterogeneous Fluid Membranes

•

Mediated Interactions

•

Liquid-Crystals

•

Mu-M

•

Curvature

•

Vacuum

•

Aggregation

•

Proteins

•

Stress

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPBITBOL  
Available on Infoscience
March 3, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/167044
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