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  4. Can Knowledge Transfer Techniques Compensate for the Limited Myocardial Infarction Data by Leveraging Haemodynamics? An <i>in silico</i> Study
 
conference paper

Can Knowledge Transfer Techniques Compensate for the Limited Myocardial Infarction Data by Leveraging Haemodynamics? An in silico Study

Tenderini, Riccardo  
•
Betti, Federico
•
Senouf, Ortal Yona  
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Juarez, JM
•
Marcos, M
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January 1, 2023
Artificial Intelligence In Medicine, Aime 2023
21st International Conference on Artificial Intelligence in Medicine (AIME)

The goal of this work is to investigate the ability of transfer learning (TL) and multitask learning (MTL) algorithms to predict tasks related to myocardial infarction (MI) in a small-data regime, leveraging a larger dataset of haemodynamic targets. The data are generated in silico, by solving steady-state Navier-Stokes equations in a patient-specific bifurcation geometry. Stenoses, whose location, shape, and dimension vary among the datapoints, are artificially incorporated in the geometry to replicate coronary artery disease conditions. The model input consists of a pair of greyscale images, obtained by postprocessing the velocity field resulting from the numerical simulations. The output is a synthetic MI risk index, designed as a function of various geometrical and haemodynamic parameters, such as the diameter stenosis and the wall shear stress (WSS) at the plaque throat. Moreover, the Fractional Flow Reserve (FFR) at each outlet branch is computed. The ResNet18 model trained on all the available MI labels is taken as reference. We consider two scenarios. In the first one, we assume that only a fraction of MI labels is available. For TL, models pretrained on FFR data - learned on the full dataset - reach accuracies comparable to the reference. In the second scenario, instead, we suppose also the number of known FFR labels to be small. We employ MTL algorithms in order to leverage domain-specific feature sharing, and significant accuracy gains with respect to the baseline single-task learning approach are observed. Ultimately, we conclude that exploiting representations learned from haemodynamics-related tasks improves the predictive capability of the models.

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Type
conference paper
DOI
10.1007/978-3-031-34344-5_26
Web of Science ID

WOS:001295128100025

Author(s)
Tenderini, Riccardo  
•
Betti, Federico
•
Senouf, Ortal Yona  
•
Muller, O.
•
Deparis, Simone  
•
Buffa, Annalisa  
•
Abbe, Emmanuel  
Editors
Juarez, JM
•
Marcos, M
•
Stiglic, G
•
Tucker, A
Date Issued

2023-01-01

Publisher

Springer Nature

Publisher place

CHAM

Published in
Artificial Intelligence In Medicine, Aime 2023
ISBN of the book

978-3-031-34343-8

978-3-031-34344-5

Series title/Series vol.

Lecture Notes in Artificial Intelligence; 13897

ISSN (of the series)

2945-9133

1611-3349

Start page

218

End page

228

Subjects

Myocardial infarction

•

Fractional flow reserve

•

Haemodynamics

•

Knowledge transfer

•

Transfer learning

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Multitask learning

•

Coronary angiography

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SCI-SB-SD  
LTS4  
MNS  
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Event nameEvent acronymEvent placeEvent date
21st International Conference on Artificial Intelligence in Medicine (AIME)

Portoroz, SLOVENIA

2023-06-12 - 2023-06-15

FunderFunding(s)Grant NumberGrant URL

Center for Intelligent Systems (CIS) at EPFL

Swiss National Science Foundation (SNSF)

200021 197021

Swiss National Science Foundation (SNSF)

200021_197021

Available on Infoscience
January 31, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/246100
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