Adaptive Exponential Integrate-and-Fire Model as an Effective Description of Neuronal Activity

• Published in: J. Neurophysiol. (ISSN: 0022-3077), vol. 94, p. 3637 - 3642
• American Physiological Society, 2005

We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (±2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.

Note: article

Reference

• LCN-ARTICLE-2005-008
• doi:10.1152/jn.00686.2005
• View record in Web of Science

Record created on 2006-12-12, modified on 2012-03-21