The increasing usage of nonlinear analyses for the design of reinforced concrete structures and the necessity of codes of practice to provide a consistent safety format for them is one of the challenges that new generations of codes of practice are facing. Suitable safety formats shall thus account for the peculiarities of nonlinear analysis, such as the possibility of having multiple potential failure modes. In this paper, the applicability of the classical Partial Safety Factor Format (PSFF) for the resistance of reinforced concrete structures (composed of two safety factors: gamma C for concrete compressive strength and gamma S for reinforcement yield strength) is investigated accounting for the possibility of multiple failure modes in nonlinear analysis. In addition, the similarities between nonlinear analysis and typical simple cases in the design of structural concrete are shown. Reliability analysis is performed for the design resistance of concrete structures according to PSFF under different design situations (crosssectional resistance or load-bearing capacity of structural elements and of simple structural systems). The results show that the PSFF applied to material strength variables leads to a satisfactory level of reliability, independently of the development of different failure modes induced by material uncertainties in nonlinear analysis. In addition, it is also observed that the simplification of integrating geometrical and model uncertainties into the partial safety factors for material strength variables can potentially underestimate their influence on the structural reliability in some cases. The case studies shows that occurrence of multiple failure modes can result into significantly different distribution characteristics between the tail and most probable region of the resistance of concrete structures. Attention should also be paid to a proper tail approximation of the probability distribution of the resistance when calibrating safety formats for concrete structures.