A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and β-sheet formation of amyloidogenic peptides.
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Awad, L., Jejelava, N., Burai, R., & Lashuel, H. A. (2016). A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides. Chembiochem : A European Journal of Chemical Biology, 17(24), 2353–2360. https://doi.org/10.1002/cbic.201600474
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WOS:000392934100011
2016
17
24
2353
2360
NON-REVIEWED
EPFL