Provisions for punching shear design of reinforced concrete slabs are usually calibrated on the basis of results from tests on isolated specimens that simulate the slab zone within the points of contraflexure around a column. However, the punching behavior of interior slab-column connections in actual continuous slabs without transverse reinforcement may be influenced by the effects of moment redistribution and compressive membrane action, which can lead to higher punching strengths and lower deformation capacities compared to those in isolated specimens. This paper discusses these behavioral differences on the basis of experiments performed on symmetric edge-restrained slabs and investigates available test data by means of a numerical model. A simplified calculation method (based on the Critical Shear Crack Theory) that accounts for these effects is also proposed. The calculation model shows consistent agreement with the results of the numerical evaluation and is sufficiently simple to be used in design and assessment.