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  4. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
 
research article

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Trompette, Aurélien
•
Gollwitzer, Eva S.
•
Yadava, Koshika
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2014
Nature medicine

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the lung, is poorly understood. We found that dietary fermentable fiber content changed the composition of the gut and lung microbiota, in particular by altering the ratio of Firmicutes to Bacteroidetes. The gut microbiota metabolized the fiber, consequently increasing the concentration of circulating short-chain fatty acids (SCFAs). Mice fed a high-fiber diet had increased circulating levels of SCFAs and were protected against allergic inflammation in the lung, whereas a low-fiber diet decreased levels of SCFAs and increased allergic airway disease. Treatment of mice with the SCFA propionate led to alterations in bone marrow hematopoiesis that were characterized by enhanced generation of macrophage and dendritic cell (DC) precursors and subsequent seeding of the lungs by DCs with high phagocytic capacity but an impaired ability to promote T helper type 2 (TH2) cell effector function. The effects of propionate on allergic inflammation were dependent on G protein-coupled receptor 41 (GPR41, also called free fatty acid receptor 3 or FFAR3), but not GPR43 (also called free fatty acid receptor 2 or FFAR2). Our results show that dietary fermentable fiber and SCFAs can shape the immunological environment in the lung and influence the severity of allergic inflammation.

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Type
research article
DOI
10.1038/nm.3444
Web of Science ID

WOS:000330915000017

Author(s)
Trompette, Aurélien
Gollwitzer, Eva S.
Yadava, Koshika
Sichelstiel, Anke K.
Sprenger, Norbert
Ngom-Bru, Catherine
Blanchard, Carine
Junt, Tobias
Nicod, Laurent P.
Harris, Nicola L.  
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Date Issued

2014

Publisher

Nature Publishing Group

Published in
Nature medicine
Volume

20

Start page

159

End page

166

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPHARRIS  
Available on Infoscience
January 30, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/100260
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