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research article
Total Synthesis and Biological Evaluation of Jerantinine E
The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary investigations show that it inhibits the polymerization of tubulin, displaying significant cytotoxicity and antimigratory activity against both breast and lung cancer cell lines.
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ACIE2013-13373GreenAccess.pdf
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openaccess
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2.79 MB
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Adobe PDF
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