Magnetic core shell nanoparticles trapping in a microdevice generating high magnetic gradient

• Published in: Lab On A Chip (ISSN: 1473-0197), vol. 11, num. 5, p. 833-840
• Royal Society of Chemistry, 2011

Magnetic core shell nanoparticles (MCSNPs) 30 nm diameter with a magnetic weight of 10% are usually much too small to be trapped in microfluidic systems using classical external magnets. Here, a simple microchip for efficient MCSNPs trapping and release is presented. It comprises a bed of micrometric iron beads (6-8 mu m diameter) packed in a microchannel against a physical restriction and presenting a low dead volume of 0.8 nL. These beads of high magnetic permeability are used to focus magnetic field lines from an external permanent magnet and generate local high magnetic gradients. The nanoparticles magnetic trap has been characterised both by numerical simulations and fluorescent MCSNPs imaging.

Keywords: Microfluidic Channel ; Chip ; Immunoassay ; Particles ; Systems ; Separation ; Poly(Dimethylsiloxane) ; Capabilities ; Fabrication ; Devices

Reference

• EPFL-ARTICLE-171729
• doi:10.1039/c0lc00510j
• View record in Web of Science

Record created on 2011-12-16, modified on 2012-03-21