Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers
 
research article

Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers

Wedeen, V. J.
•
Wang, R. P.
•
Schmahmann, J. D.
Show more
2008
Neuroimage

MRI tractography is the mapping of neural fiber pathways based on diffusion MRI of tissue diffusion anisotropy. Tractography based on diffusion tensor imaging (DTI) cannot directly image multiple fiber orientations within a single voxel. To address this limitation, diffusion spectrum MRI (DSI) and related methods were developed to image complex distributions of intravoxel fiber orientation. Here we demonstrate that tractography based on DSI has the capacity to image crossing fibers in neural tissue. DSI was performed in formalin- fixed brains of adult macaque and in the brains of healthy human subjects. Fiber tract solutions were constructed by a streamline procedure, following directions of maximum diffusion at every point, and analyzed in an interactive visualization environment (TrackVis). We report that DSI tractography accurately shows the known anatomic fiber crossings in optic chiasm, centrum semiovale, and brainstem; fiber intersections in gray matter, including cerebellar folia and the caudate nucleus; and radial fiber architecture in cerebral cortex. In contrast, none of these examples of fiber crossing and complex structure was identified by DTI analysis of the same data sets. These findings indicate that DSI tractography is able to image crossing fibers in neural tissue, an essential step toward non-invasive imaging of connectional neuroanatomy. (c) 2008 Published by Elsevier Inc.

  • Details
  • Metrics
Type
research article
DOI
10.1016/j.neuroimage.2008.03.036
Web of Science ID

WOS:000256620400010

Author(s)
Wedeen, V. J.
Wang, R. P.
Schmahmann, J. D.
Benner, T.
Tseng, W. Y. I.
Dai, G.
Pandya, D. N.
Hagmann, P.  
D'Arceuil, H.
de Crespignya, A. J.
Date Issued

2008

Publisher

Elsevier

Published in
Neuroimage
Volume

41

Start page

1267

End page

1277

Subjects

magnetic resonance imaging

•

diffusion spectrum imaging

•

diffusion tensor imaging

•

fiber crossing

•

neuroanatomy

•

Persistent Angular Structure

•

Human Brain Connectivity

•

Mri Data

•

Tracking

•

Architecture

•

Simulations

•

Orientation

•

Pathways

•

Insights

•

Stroke

•

LTS5

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTS5  
Available on Infoscience
November 30, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/61293
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés