Preclinically assessed optimal control of postprandial glucose excursions for type 1 patients with diabetes

• Presented at: 7th Annual IEEE Conference on Automation Science and Engineering (CASE 2011), Trieste, Italy, August 24-27, 2011
• Published in: Proceedings of the 2011 IEEE Conference on Automation Science and Engineering, p. 702-707
• Publication date: 2011

Type 1 Patients with Diabetes (Type 1 PwDs) have to frequently adjust their insulin dosage to keep their Blood Glucose concentration (BG) within normal bounds. Meal intakes represent the most important disturbance that has to be accounted for. Its effect differs for every individual as well as for every meal. These specificities are automatically taken into account in the approach proposed in this paper. Model parameters are identified for every couple (Patient, Meal) of interest and optimal control is applied to generate individualized meal specific insulin profiles. The method does not require the use of a continuous BG meter, the profiles being infused in an open-loop manner. Results from a preliminary clinical study are presented. The concept is shown to be effective, despite limitations due to the aggressive execution chosen. Improvements are proposed and a possible pratical implementation is described.

Keywords: Biomedical Systems ; Physiological models ; Type 1 Diabetes Mellitus ; Optimal Control ; Parameter Identification

Reference

• EPFL-CONF-153319

Record created on 2010-10-18, modified on 2012-03-20