This paper studies the effect of a robot’s design (appearance) in facilitating and encouraging interaction of children with autism with a small humanoid robot. The paper compares the children’s level of interaction with and response to the robot in two different scenarios: one where the robot was dressed like a human (with a ‘pretty- girl’ appearance) with an uncovered face, and the other when it appeared with plain clothing and with a featureless, masked face. The results of these trials clearly indicate the children’s preference in their initial response for interaction with a plain, featureless robot over interaction with a human like robot.